Selected Publications:
Guixà-González R, Albasanz JL, Rodriguez-Espigares I, Pastor M, Sanz F, Martí-Solano M, Manna M, Martinez-Seara H, Hildebrand PW, Martín M, Selent J
Membrane cholesterol access into a G-protein-coupled receptor.
Nat Commun 2017; 8(14505):doi: 10.1038/ncomms14505.
- Cholesterol spontaneously enters a GPCR-binding pocket from the membrane milieu
- Cholesterol uses the same portal gate previously suggested for opsin ligands
- Presence inside the receptor confirmed in a biotinylation assay
- Cholesterol's impact on GPCR-binding affinity goes beyond pure allosteric modulation
- New interaction mode between cholesterol and a GPCR shown